Heptadrol is the next generation of muscle building prohormones which includes the never before seen Androsterone Acetate and our Patent Pending 3-AD(TM).
Heptadrol™ 500mg Myotrophic Hormone Blend + 75mg TetraSorb™ Delivery Matrix per Serving
Heptadrol is an all-in-one bodybuilding and muscle building prohormones supplement with 7 potent all-natural steroids and Nutraceutical Innovations’ exclusive TetraSorb delivery technology. It’s twice the strength of the competition, with more ingredients and stronger hormones, plus a new and exciting bonus ingredient you’ll be the first to try!
Epiandrosterone is a precursor to DHT (aka: Stanolone) which is the primary androgen in men, and quite potent. By virtue of its reduced structure, it does not aromatize into estrogen, so side effects like gyno, water retention, etc. are rarely encountered. It is particularly effective at promoting strength and increasing muscular definition.
Epiandrosterone is estimated to be only about 2.1% as androgenic as Testosterone, so it’s not too surprising that its HPTA suppressive potential is low. However, some of its metabolites are distinctly suppressive, so extended use should be terminated with a ramp-down at minimum, or more appropriately with a proper PCT to guard against post-cycle complications.
Also, as a negative GABAnergic modulator, Epiandrosterone may have stimulatory effects in sensitive individuals. It is therefore recommended that Heptradrol not be taken too close to sleep.
Androstenolone / DHEA (Androst-5-ene-3b-ol-17-one)
DHEA is a natural steroid hormone which is biosynthesized predominately in the adrenals. It possesses about 2.0% of the androgenicity of Testosterone. Blood levels are relatively high in adolescence but begin to decline rapidly in young adulthood. It is commonly used to promote bone density, support lean muscle mass and hardness, alleviate depression, encourage libido, improve immune function, and sooth inflammatory conditions without the need for catabolic corticoids. Decades of research are available to support the utility of DHEA in these applications, and all these applications can be particularly pertinent to athletes. For example, supraphysiological doses of DHEA increase serum levels of several anabolic androgens. These androgens include the once popular but now scheduled steroid Androstenedione, and conjugated metabolites of DHT like Androsterone. However, concentrations of undesirable hormones like Cortisol and Aldosterone appear unaffected by DHEA administration.
But what about estrogen? Most bros on the internet say DHEA is estrogenic!
In reality, increases in estrogen (E1 and E2), DHT and Testosterone are statistically non-existent, except in women where Testosterone levels can be significantly elevated over their already low baseline.
How can DHEA possesses all these positive attributes with high oral dosing, but not suppress adrenal or testicular axis?
To understand this, we must turn to the field of Endocrinology known as Intracrinology. Basically, all enzymes needed to convert DHEA into androgens are expressed in a cell-specific fashion in the peripheral target tissues. This allows the androgen-sensitive tissues like muscle to use DHEA locally, and control the intracellular concentrations of these newly formed androgens on-site. This means that oral supplementation with exogenous DHEA enables regulated production of androgens, only in appropriate target tissues, without leakage of significant amounts of metabolites into the general circulation. This local/intracrine action minimizes the inappropriate exposure of other tissues to androgens, virtually eliminating the risk of undesirable systemic effects such as testicular shut-down. But besides the utility of DHEA as an androgen precursor in target tissue, research has also noted an inverse relationship between cardiovascular mortality and plasma DHEA levels in men. This anti-atherogenic action, and reduction in vascular dysfunction is very intriguing. It is commonly believed that estrogen is “heart-healthy” but that androgens are not, so how can this be? In endothelial cells, DHEA is demonstrated to increase the expression of nitric oxide synthase (NOS) and the subsequent secretion of nitric oxide (NO), which is commonly known to regulate the vascular system in a positive way for athletes. NO products are quite abundant these days, and everyone seems to love the pump that NO boosters provide, but DHEA has it all. It offers the positive cardiovascular pump and skeletal benefits of estrogens, plus the muscle-enhancing properties of androgens, without the elevated blood levels or side effects of either.
DHEA is also generally observed to decrease Sex Hormone-Binding Globulin (SHBG) and increase IGF-1 levels in the blood. These are both highly desirable effects because they discourage feedback suppression and promote additional growth. Another encouraging observation is that HCG treatment increases intratesticular DHEA concentrations. This makes a strong argument for the steroidogenic action of DHEA, rather than any suppressive potential, but this is not yet fully characterized. In addition to these peripheral steroidogenic effects, DHEA may also promote central steroidogenic processes by interaction with the NMDA receptor. This is only speculation because LH studies with consistent results in healthy men are hard to find.
So what’s the practical potential of DHEA?
In the gym (real world) DHEA can be expected to promote muscular density and hardness after just a few days of use. This rapid response seems related to its notable insulinomimetic activity, which is crucial to the anabolic effect of androgens. It also works well in practically any stack, and doesn’t induce any discernable estrogenic or corticogenic sides. On paper, HPTA suppression may be possible. However, it has never actually been observed by this author in himself or any other athlete and is therefore considered extremely unlikely. 11-KT (Androst-4-ene-17b-ol-3,11-dione) 11-Ketotestosterone (11-KT) is a hormone naturally present in both men and women. It is biosynthesized from at least 3 known enzymatic pathways in the body, with adrenal precursors accounting for the majority. In the testes, 11-KT is believed to reduce levels of Glucocorticoids, thus minimizing their suppressive influence on steroidogenesis. This means 11-KT might actually boost Testosterone levels at physiological concentrations. In women, 11-KT also plays a part in folliculogenesis, suggesting an essential reproductive role in humans.
11-KT is also present in other species. For example, it is the primary androgen in fish, so meat eaters likely ingest it in the diet quite often. The details of its metabolism are not fully characterized, but can be reasonably anticipated to follow a pattern similar to that of Adrenosterone (11-Oxo.)
Speaking of Adrenosterone, is 11-KT also a good repartitioner? 11-KT is a moderate inhibitor of an enzyme called 11b-Hydroxysteroid Dehydrogenase Type 1 (11b-HSD1), which reduces Cortisol levels in sensitive tissues. High levels of Glucocorticoids promote adipocyte differentiation, which results in increased deposition of fat and increased hepatic glucose production and subsequent insulin resistance. Thus, 11b-HSD1 inhibitors like 11-KT can be useful as Cortsiol antagonists and weight loss promoters. Anecdotal evidence suggests that 11-KT shares similar effectiveness with 11-Oxo.
Animal research using transcriptional analysis techniques suggest that 11-KT activates the Androgen Receptor (AR) with similar potency to Testosterone, but less profoundly than DHT (the primary androgen in man.) So while there is no consensus on its relative potency, users do report that its subjective effects are definitely worthwhile.
Androsterone-3-Acetate (5a-Androstan-3a-ol-17-one Acetic Acid Ester)
Androsterone retains about 12.5-15.0% of Testosterone’s androgenicity, so while it is somewhat similar to Epiandrosterone in structure, it is considerably more virilizing qualitatively. It’s decidedly more potent quantitatively as well, and this makes it an excellent pre-workout or pre-competition addition to enhance alpha attitude and competitive aggression. This sensation is commonly referred to as feeling “on” and Androsterone delivers it.
Androsterone blood levels and ratios are also a prominent marker for sexual preference, with high Androsterone levels corresponding to a stronger desire for women. Men with high Androsterone levels are also perceived more positively by women, who tend to view them as trusted alpha types. There are several Androsterone derivates available on the market today, usually labeled erroneously as “DHEA” with a number next to them, but don’t be fooled. They are not truly DHEAs, and few of them share the potency or benefit of real Androsterone either. We use the Acetate ester of Androsterone in Heptadrol, which may prove to be a superior form based on its enhanced lipophilicity.
11-Oxo / Adrenosterone (Androst-4-ene-3,11,17-trione)
Adrenosterone is an adrenal corticoid with impressive endocrine activity. Vida indicates an anabolic potency which is ~70% that of Testosterone, but with less than half the androgenicity. Sounds great so far. But what we didn’t know at first was how good a fat-burner it would prove to be. During beta testing with volunteers, some were reporting extreme weight loss. There was concern because this is supposed to be an anabolic gainer, and some of our heavier testers were losing weight in the double digits! As it turns out, these were the testers who already had some fat to lose, but their strength was soaring as the fat melted away and they all reported feeling great. Libido enhancement is also sometimes reported.
Adrenosterone is widely considered to be a top-shelf, low side effect, lean mass gainer. It also has cortisol lowering effects related to its enzyme inhibiting properties, making it ideally suited for shredding body fat without going catabolic on cutting cycles. Significant testicular shut-down is uncommon with Adrenosterone. Nevertheless, a mild PCT is recommended after use.
Beta-AET significantly counteracts the immunosuppressive effects of Hydrocortisone on lymphocyte proliferation and cytokine production. It upregulates host immunity, leading to increased resistance against infections. AET augments IL-2, IL-3 and IFN-gamma levels, which are the pertinent cytokines referenced previously. AET has been shown to induce a more rapid recovery of all hematopoietic precursors from surviving stem cells after gross irradiation with otherwise lethal doses of ionizing emissions.
OK, but what’s the practical significance of this data as it relates to weight training?
AET is a potent immune booster, but the mechanism is the interesting part. It does this because it’s a potent Glucocorticoid antagonist, and that’s the reason for its inclusion in Heptadrol! This effect is not anabolic but rather anti-catabolic, which offers another pathway to the same goal – gain and keep as much muscle as possible without the fat!
3-AD™ / Dehydroandrosterol (Androst-5-ene-3a,17b-diol) Last but not least, we’ve included our all new, patent pending super-star ingredient, 3-AD! This endogenous hormone has been largely overlooked until now, but was shown to possess potent androgenic activity as far back as 1944 by Koch.
Below is a comparison assembled by Gisvold et al, measuring relative androgenic potency of various androgens. Percentages are calculated from Micrograms Equivalent to an International Unit, with Testosterone being the comparative standard (15IU = 100%):
75.0% DHT 54.5%
43.9% 3-AD / Dehydroandrosterol (Δ5-Androstene-3a,17b-diol)
12.5% Andro (Δ4-Androstenedione)
3.0% 5-AD (Δ5-Androstene-3b,17b-diol)
2.0% DHEA (Dehydroepiandrosterone)
By comparison, it is apparent that 3-AD shows impressive androgenic potency, being about 3x stronger that Androsterone and possessing roughly 80% the androgenic strength of Methyltestosterone!
While it may be obscure, 3-AD is no less a recognized endogenous hormone in animals, and it’s exogenous administration is expressly prohibited by some sports organizations such as WADA.
Professional athletes under contract should check the doping rules of their specific organization prior to use of 3-AD or Heptadrol!
Is this estrogenic like 5-AD, or alopecic like 3a-Diol?
“3a-Diol” generally refers to 5a-Androstane-3a,17b-diol, a prominent DHT metabolite associated with alopecia. 3a-Diol is a generic term and should not be confused with 3-AD! 3-AD is not a DHT metabolite, but rather observed to be biosynthesized in man predominately from Dehydroandrosterone (DHA) via 5-Androstenedione via DHEA. Since 5-Androstenedione does not back-metabolize to DHEA or DHT, 3-AD does not appear capable of raising DHEA, 5-AD or 3a-Diol levels. Therefore, estrogenic and alopecic metabolites of 3-AD should be negligible or absent, and the majority of its biological effects are likely attributable to unmetabolized Dehydroandrosterol and its oxidized metabolite DHA.
Recently, studies by Gillete et al (among others) have noted that Delta-5 compounds like 3-AD have an amplifying effect on most other endogenous steroids, so 3-AD not only has potent androgenic action on its own, but also makes an excellent synergistic addition to multi-ingredient products like Heptadrol!
Serving Size: 1 Capsule
Servings per Container: 30
Heptadrol Muscle Matrix: 575mg
Other Ingredients: See Supplement Facts above
For optimal results take 1 serving daily upon waking. Do not exceed 2 capsules in a 24 hour period. Typical cycle length is 4-8 weeks.
How to Stack: Heptadrol has multiple anabolic compounds making it a solid overall supplement by itself. However it stacks well with an estrogen blocker, like our ArimaMax.
Typical cycle length is 4-8 weeks, we recommend using Heptadrol for at least 30 consecutive days. Once you have completed your cycle of Heptadrol, we recommend taking Robust Thrust which is an all-around testosterone booster, estrogen blocker and male enhancer designed to restore natural hormone levels.